DEVELOPMENT OF A BISPECIFIC NANOBODY CONJUGATE BROADLY NEUTRALIZES DIVERSE SARS-COV-2 VARIANTS AND STRUCTURAL BASIS FOR ITS BROAD NEUTRALIZATION.

Development of a bispecific nanobody conjugate broadly neutralizes diverse SARS-CoV-2 variants and structural basis for its broad neutralization.

The continuous emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increased transmissibility and profound immune-escape capacity makes it an urgent need to develop broad-spectrum therapeutics.Nanobodies have recently attracted extensive attentions due to their excellent biochemical and binding properties.Here, w

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HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia

Cervical cancer is the second most common cause of death from cancer in women worldwide, and the development of new diagnostic, prognostic, and treatment strategies merits special attention.Many efforts have been made to design new drugs and develop immunotherapy and gene therapy strategies to treat cervical static nail coupon cancer.HPV genotyping

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